Periampullary adenocarcinoma, including pancreatic cancer, has a poor prognosis that has not improved in the
last decades. Therefore, in order to find more effective treatment regimens, it is necessary to gain more insight
into the biology and clinical behaviour of these tumours.
This thesis entails a thorough histopathological characterization of retrospectively collected tumours from a
consecutive cohort of patients with resected periampullary adenocarcinoma, followed by tissue microarray-based
immunohistochemical studies of eight candidate protein biomarkers. Tumours were classified as being of
pancreatobiliary type (PB-type) or intestinal type (I-type), using histological criteria, and all biomarker analyses
were performed in strata according to morphological type.